Equipment Model

Agilent Technologies 1290 Infinity II Bio-LC

Description

The 1290 Infinity II Bio-LC system is an ultra-high-performance liquid chromatography (UHPLC) instrument designed for high-speed, high-sensitivity, and precise analytical performance.

Lab

MCBR

Institute

Manipal Centre for Biotherapeutics Research (MCBR)

Location

1st Floor, Manipal Centre for Biotherapeutics Research, Eshwar Nagar, Manipal, Udupi, Karnataka 576104, India

• Applications

  • Protein purification

  • Monoclonal antibody analysis

  • Peptide mapping

  • Nucleic acid analysis

  • Size exclusion chromatography (SEC)

  • Glycan analysis

  • Enzyme purification and kinetic studies

  • Metabolomics

  • Phosphoprotein analysis

  • Exosome-drug loading and release study

  • Methylation experiments for DNA and RNA (epigenetics and epitranscriptomics studies)

• Clinical Applications

  • Pharmacokinetic studies

  • Therapeutic drug monitoring (TDM)

  • Clinical toxicology

  • Food allergen testing

  • Environmental exposure assessment

  • Studies on inflammatory markers

  • Biochemical marker analysis

  • Proteomics and peptidomics

  • Metabolomics

  • Analysis of nucleic acids

• Key Features

  • Ultra-high-performance separation with superior resolution and sensitivity.

  • Bio-inert system to ensure compatibility with biomolecules.

  • Future upgradability options for enhanced performance.

  • Non-metallic tubing and columns to prevent sample contamination.

  • Supports a wide range of applications in pharmaceuticals, biotechnology, and clinical research.

• Limitations

  • Higher operational and maintenance costs compared to standard HPLC.

  • Requires specialized training for method development and troubleshooting.

  • Not suitable for all types of complex biological samples without method optimization.

  • Sensitive to variations in column packing and solvent quality.