Equipment Model

Panlab LE8300

Description

The Panlab LE8300 Rota Rod is a specialized apparatus designed to assess motor coordination, balance, and endurance in rodents. It features a rotating rod that can operate at constant or accelerating speeds, challenging the animal's ability to maintain balance. The device records the latency to fall, providing quantitative data on motor performance. The LE8300 model is tailored for rats, accommodating up to four subjects simultaneously.

Lab

MW Room - 2

Institute

Central Animal Research Facility

Location

Central Animal Research Facility, Opposite MSLS, Eshwar Nagar, Manipal, Udupi, Karnataka 576104, India

• Applications

  • Motor Coordination Studies: Evaluating the effects of neurological disorders or interventions on balance and coordination.

  • Pharmacological Testing: Assessing the impact of drugs on motor functions.

  • Genetic Research: Studying motor deficits in genetically modified rodent models.

  • Aging Studies: Investigating age-related declines in motor performance.

  • Toxicology: Monitoring motor impairments due to exposure to toxic substances.

• Key Features

  • Adjustable Speed: Operates at constant speeds ranging from 4 to 40 rpm.

  • Acceleration Mode: Allows for acceleration over predefined durations (e.g., 30 sec, 1, 2, 5, or 10 min).

  • Individual Timers: Each lane is equipped with an independent timer to record latency to fall.

  • Data Output: Equipped with an RS-232 interface for data export to PC-compatible formats.

  • Safety Features: Includes a removable hood to prevent animals from escaping and to minimize distractions.

  • Construction: Made with durable materials suitable for repeated use in laboratory settings.

• Limitations

  • Species Specificity: The LE8300 is designed for rats; using it with smaller rodents like mice may require modifications.

  • Learning Curve: Animals may require training sessions to acclimate to the apparatus.

  • Stress Factors: The testing environment and procedure may induce stress, potentially affecting results.

  • Maintenance: Regular calibration and cleaning are necessary to ensure accurate measurements.

  • Data Interpretation: Variability in performance may arise due to factors unrelated to motor ability, such as motivation or fatigue.